Nuclear imaging for immune cell tracking in vivo – Comparison of various cell labeling methods and their application

There is currently great interest in the development of cell-based therapies, particularly those focused on idea exploiting systemically administered immune cells for therapeutic purposes cancer (e.g., CAR-T and CAR-NK cells). The ability to monitor fate vivo after administration vital assessment outcomes therapies both preclinical research clinical practice. In this context, imaging techniques, which allow noninvasive real-time monitoring distribution long-term viability adoptively transferred tissue interest, are paramount importance. Among clinically relevant modalities, nuclear comprising planar scintigraphy, SPECT, PET, considered be pivotal importance cell tracking designing optimal treatment strategies therapies. This review paper focuses its role evaluation therapies’ effectiveness - their home target tissue. We compare different types radiotracers, outline various ways labeling, provide latest examples use techniques studies settings.